Cellular pathology of multiple system atrophy: a review.

cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome). Metal-catalyzed oxidation renders silver intensifica-tion selective. Application for the histochemistry of diaminobenzidine and neurofibrillary changes. 6 Horoupian DS, Dickson DW. Striatonigral degeneration, olivopontocere-bellar atrophy and "atypical" Pick disease. ubiquitinated cytoplasmic inclusions of Leu-7-positive glial cells in olivopontocerebellar atrophy (multiple system atrophy). Argyrophilic glial intracytoplasmic inclusions in multiple system atrophy: immunocytochemical and ultrastructural study.cytochemical and ultrastructural studies of neuronal and oligoden-droglial cytoplasmic inclusions in multiple system atrophy. 2. et al. Cytoskeletal protein abnormalities in patients with olivopontocerebellar atrophy-an immunocyto-chemical and Gallyas silver impregnation study. Immunohistochemical expression of microtubule-associated protein 5 (MAP5) in glial cells in multiple system atrophy. Phosphorylated high molecular weight neurofilament protein in the peripheral motor, sensory and sympathetic neuronal perikarya: system-dependent normal variations and changes in amyotrophic lateral sclerosis and multiple system atrophy. The distribution of oligodendroglial inclusions in multiple system atrophy and its relevance to clinical symptomatology. Larrey, chief surgeon of Napoleon's grand army, added new dimension to military medicine, in particular, sanitation , epidemiology, procurement of food and supplies for the sick and wounded, training of medical personnel, transport of the injured, and provision for definitive care at the front. He took part in 60 battles and 400 engagements. Larrey instituted immediate care on the battlefield and "flying ambulances" for the rapid evacuation of the wounded from the field of action. Incredible numbers of wounded passed through his hands, affording him enormous clinical experience. An ardent advocate of early amputation he performed as many as 200 in a single day. Large numbers of disarticulations at the shoulder joint and even at the hip joint, with a high incidence of recovery were performed at the front or on the battlefield without anaesthesia. Other major operative procedures included trephining, thoracotomy, and the treatment of penetrating wounds to the abdomen. In his Memoir on traumatic tetanus, amputation of the limb at the first appearance of the symptoms was advised. He cites numerous reports of patients salvaged by this operation. after those of Ambrose Pare, provide a fascinating record of the campaigns, medical problems encountered, and the scenes and customs of the many lands traversed by the grand army.